Alan J Warren Selected Research

Shwachman-Diamond Syndrome

1/2019	EFL1 mutations impair eIF6 release to cause Shwachman-Diamond syndrome.
1/2018	Molecular basis of the human ribosomopathy Shwachman-Diamond syndrome.
11/2015	Mechanism of eIF6 release from the nascent 60S ribosomal subunit.
5/2011	Uncoupling of GTP hydrolysis from eIF6 release on the ribosome causes Shwachman-Diamond syndrome.
4/2007	The Shwachman-Bodian-Diamond syndrome protein mediates translational activation of ribosomes in yeast.

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Alan J Warren Research Topics

Disease

5	Shwachman-Diamond Syndrome 01/2019 - 04/2007
4	Leukemia 11/2015 - 04/2007
2	Neoplasms (Cancer) 01/2022 - 08/2008
2	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 01/2016 - 08/2008
2	Genetic Translocation (Chromosomal Translocation) 01/2016 - 10/2006
1	Autosomal Recessive 3 Severe Congenital Neutropenia 01/2022
1	B-Cell Chronic Lymphocytic Leukemia (Chronic Lymphocytic Leukemia) 01/2021
1	Disease Progression 01/2021
1	Traumatic Brain Injuries (Traumatic Brain Injury) 01/2018
1	Myelodysplastic Syndromes (Myelodysplastic Syndrome) 01/2016
1	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia) 11/2015
1	Confusion (Bewilderment) 02/2014
1	Poikiloderma with Neutropenia 02/2013
1	Aplastic Anemia (Anemia, Hypoplastic) 06/2012
1	Chromosome 5q Deletion Syndrome 11/2010
1	Macrocytic Anemia 01/2010
1	Bone Marrow Failure Disorders 04/2007
1	Polycythemia Vera 02/2007
1	Polycythemia (Erythrocytosis) 02/2007
1	Primary Myelofibrosis (Myelosclerosis) 02/2007
1	Essential Thrombocythemia 02/2007
1	Hypersensitivity (Allergy) 03/2006

Drug/Important Bio-Agent (IBA)

7	Proteins (Proteins, Gene)FDA Link 01/2021 - 10/2006
2	GTP Phosphohydrolases (GTPases)IBA 01/2019 - 11/2015
2	DNA (Deoxyribonucleic Acid)IBA 01/2016 - 10/2006
2	Ribosomal Proteins (Ribosomal Protein)IBA 02/2014 - 11/2010
1	Oncogene Proteins (Oncogene Protein)IBA 01/2022
1	Leukocyte Elastase (Neutrophil Elastase)IBA 01/2022
1	Peptide Elongation Factors (Elongation Factor)IBA 01/2019
1	Eukaryotic Initiation Factor-2B (Eukaryotic Initiation Factor 2B)IBA 01/2018
1	NucleotidesIBA 01/2016
1	RicinIBA 11/2015
1	Peptide Elongation Factor G (EF G)IBA 11/2015
1	U6 small nuclear RNAIBA 02/2013
1	thymoglobulin FDA Link 06/2012
1	Cyclosporine (Ciclosporin)FDA LinkGeneric 06/2012
1	Guanosine Triphosphate (GTP)IBA 05/2011
1	MicroRNAs (MicroRNA)IBA 11/2010
1	ribosomal protein S14IBA 01/2010
1	NucleophosminIBA 08/2008
1	Phenylalanine (L-Phenylalanine)FDA Link 02/2007
1	Erythropoietin FDA Link 02/2007
1	Valine (L-Valine)FDA Link 02/2007
1	Janus KinasesIBA 02/2007
1	Transcription Factors (Transcription Factor)IBA 03/2006
1	RNA Polymerase II (RNA Polymerase B)IBA 03/2006
1	ChromatinIBA 03/2006

Therapy/Procedure

1	Therapeutics 08/2008
1	Bone Marrow Transplantation (Transplantation, Bone Marrow) 02/2007